![]() In response to extracellular cues, transmembrane receptors are activated and stimulate a variety of intracellular biochemical pathways. Signal transducing receptors fall into three general classes: ( i) transmembrane receptors with intrinsic enzymatic activity ( ii) transmembrane receptors coupled to GTP-binding and hydrolyzing proteins (G proteins e.g., the adrenergic receptors and some hormone receptors) and ( iii) intracellular receptors in the steroid/thyroid hormone receptor superfamily, which upon binding to their ligand, form a complex that migrates to the nucleus, affecting gene transcription. Signaling molecules include neurotransmitters, hormones, growth factors, chemokines, and cytokines, and their activities are normally intercoordinated in precise, complex spatial and temporal processes via a large array of pathways. Signaling mechanisms regulating vascular smooth muscle cell function in the setting of vascular fibroproliferative diseases, including restenosis and pulmonary hypertension.Signal transduction, according to Sara Courtneidge, Laboratory of Signal Regulation and Cancer, Van Andel Research Institute, Grand Rapids, MI, is the process by which a cell interprets a signal from outside and translates this into growth, differentiation, apoptosis, and other activities. Novel tools to sense and manipulate the intracellular environment. Protein engineering and optogenetics, Development of Novel molecular targets relevant to papillary and anaplastic thyroid cancer (PTC and ATC) with the ultimate goal of advancing these studies to clinical trials for thyroid cancer patients who do not respond to standard treatments. PhD, 2000, University of Colorado Health Sciences Center G-protein linked receptors and their regulation regulation of mRNA stability. Signaling pathways controlling growth and differentiation of vascular smooth muscle cells Role of eicosanoids in lung cancer. Pulmonary hypertension, right heart failure, sex differences in cardiopulmonary disease, estrogen signaling in the lung and right ventricle, angiogenesis and endothelial cell function in pulmonary vascular disease and right heart failure, hypoxia-induced cardiac and lung vascular remodeling, neurohormonal signaling in right heart failure, androgen signaling in asthma.Įpigenetic regulation of heart failure signaling and transcriptional mechanisms of muscle disease. of California, San DiegoĪnd specific receptor tyrosine kinases in normal and transformed growth of lung epithelial cells using techniques of molecular and cell biology in lung epithelial cells and human lung cancer cell lines. With a focus on the role of the Six1/Eya transcriptional complex in TGF-beta signaling, epithelial to mesenchymal transition, cancer stem cells, and metastasis. My laboratory studies the parallels between normal development and tumorigenesis/metastasis Nigrostriatal circuits through their G-protein coupled receptors and the alterations that occur in these systems in neurological and psychiatric diseases. We study the synaptic mechanisms by which neuromodulators like dopamine and acetylcholine are encoded in mesolimbic and Phosphatase anchoring proteins mechanisms regulating neuronal second messenger signaling in synaptic plasticity. Organization of signaling complexes by protein kinase and We use this information to combat brain diseases with a vascular component. The control of cerebral blood flow by ionĬhannels and calcium signaling in the pericytes, endothelial cells, and smooth muscle cells that constitute the brain microcirculation. PhD, University of Bordeaux Segalen, France Studies of protein-nucleic acid and protein-protein complexes in chromatin and bacterial pathogenesis. Structure and mechanism in gene regulation biophysical and structural Shape, number and subcellular distribution in metastatic dissemination. We use a broad repertoire of biochemistry, cell biology, live cell imaging and animal models to study the impact of mitochondria Strategies for restoring normal synaptic plasticity in neurological disorders.Īims to understand how mitochondria reprogramming in tumors impact cellular behaviors that drive progressive and lethal cancer. Molecular mechanisms of synaptic plasticity. Examining structural and regulatory mechanisms of the Acid-sensing ion channels usingĮlectrophysiology, fluorescence, spectroscopy, and structural biology. ![]() Molecular Mechanisms of ion channel function. Using cutting-edge multidisciplinary techniques, we are able to interrogate these molecules with cell-type and synapse-specific We are interested in dissecting the distinct functions of synapticĬell-adhesion molecules implicated in neuropsychiatric disorders and addiction in the context of disease-relevant brain circuits.
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